BIOTECH

Cytoskeleton-related Alzheimer’s Disease Research Service

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Mechanisms of Alzheimer’s Disease Alzheimer’s disease continues to destroy brain tissue, causing patients to lose memory and experience disorientation, among other things, potentially rendering them unable to care for themselves in their daily lives. With in-depth knowledge of cytoskeleton-related research services and extensive project experience, we provide reference materials on Alzheimer’s Disease to help you … Read more

Chimeric VLP Development Service

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Overview of Chimeric VLP Development Service Virus-like particles (VLPs) can be assembled spontaneously in the viral cycle or assembled when other heterologous expression systems express viral structural proteins. VLPs are constructed from proteins of a single virus, and chimeric VLPs (cVLPs) are generated when ligands (proteins, peptides or antibodies, etc.) bind to VLPs. Therefore, cVLPs refer … Read more

Psychiatric Biomarker Testing Services

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Introduction of Psychiatric Biomarker Testing For many years, researchers have been trying to identify diagnostic and prognostic biomarkers for psychiatric disorders, including schizophrenia, major (monophasic) depression and bipolar disorder. Identifying such biomarkers will help in the diagnosis of these disorders, as well as in the possible development of effective psychiatric drugs to treat them. Fig. … Read more

Iron Metabolism-related Gene Identification in Plants

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Plants iron metabolism Among the trace elements essential for plant growth and development, iron is the most demanded and plays an essential role in important plant life activities such as photosynthesis, respiration and chlorophyll synthesis. Plant Iron Uptake Systems Over time, plants have evolved an elaborate molecular regulatory system for iron uptake, transport and metabolism … Read more

Stem Cell Therapy Development Service for T1DM

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T1DM stem cell therapy development Stem cells open up a wide spectrum of diabetes research possibilities. Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with T1DM to withdraw from insulin therapy. Furthermore, autologous transplantation using induced pluripotent stem cells-derived islet cells is expected to … Read more

Exploration of Terpenoid Biosynthesis in Filamentous Fungi

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Using synthetic biology methods allows for the more efficient production of highly complex drug molecules compared to traditional chemical methods, with increased stability and controllability. Many drug components are currently produced using expensive and unstable manufacturing methods, such as cultivating medicinal plants, leading to frequent drug shortages. By utilizing highly engineered microorganisms for microbial fermentation, the … Read more

Microbial Production of Bio-based Plastics

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At the 5th United Nations Environment Assembly (UNEA-5) held in March 2022, 175 countries signed a resolution to end plastic pollution. The aim is to achieve a legally binding international agreement by the end of 2024, addressing the entire lifecycle of plastic products, including production, design, recycling, and disposal. Addressing plastic pollution has become a global … Read more

CMC Regulatory Considerations for ADCs

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Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC drugs have been approved worldwide, of which the FDA has approved 13 ADCs for various cancers, including Adcetris®, Kadcyla®, Besponsa®, Mylotarg®, Lumoxiti®, Polivy®, Padcev®, Enhertu ®, … Read more

Hybridization-ELISA in the Bioassay of Oligonucleotide Drugs

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Introduction of Oligonucleotides Oligonucleotide-based therapeutics represent a rapidly advancing field in current drug development. According to their therapeutic mechanisms, oligonucleotide drugs can be categorized into antisense oligonucleotides (ASOs), small interfering RNA (siRNA), microRNA, anti-gene transcription factor inducers, and nucleic acid aptamers. Oligonucleotide sequences typically have lengths of around 12-30 nucleotides (nucleic acid aptamers may exceed 30 … Read more